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Your Position: Home > CD200 R1

CD200 R1

Brief Information

Name:Cell surface glycoprotein CD200 receptor 1
Target Synonym:Cell surface glycoprotein OX2 receptor 1,CD200 cell surface glycoprotein receptor,CD200R
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

Licensing

Project Name Modality Therapeutic Area Indications Stage Right Available
High selective OX1R/OX2R dual inhibitor treating insomnia Small molecule Neurological disease Insomnia Phase I Global

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Cat. No. Species Product Description Structure Purity Feature
CR2-H52H6 Human Human CD200 R1 / CRTR2 Protein, His Tag
CR2-H52H6-structure
CR2-H52H6-sds
CR2-H82F4 Human Biotinylated Human CD200 R1 / CRTR2 Protein, Fc,Avitag™
CR2-H82F4-structure
CR2-H82F4-sds
ACRO Quality

Part of Bioactivity data

CR2-H82F4-ELISA
Biotinylated Human CD200 R1, Fc,AvitagBiotinylated Human CD200 R1, Fc,Avitag (Cat. No. CR2-H82F4) ELISA bioactivity

Immobilized Human CD200, Fc Tag (Cat. No. OX2-H5251) at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD200 R1, Fc,Avitag (Cat. No. CR2-H82F4) with a linear range of 0.5-7.8 ng/mL (QC tested).

Protocol
CR2-H52H6-ELISA
Human CD200 R1, His TagHuman CD200 R1, His Tag (Cat. No. CR2-H52H6) ELISA bioactivity

Immobilized Human CD200, Fc Tag (Cat. No. OX2-H5251) at 5 μg/mL (100 μL/well) can bind Human CD200 R1, His Tag (Cat. No. CR2-H52H6) with a linear range of 20-78 ng/mL (QC tested).

Protocol

Synonym Name

CD200R,CRTR2,MOX2R,OX2R

Background

Cell surface glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene.This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. CD200 and its receptor CD200R are both type-1 membrane glycoproteins, which are members of the immunoglobulin superfamily (IgSF). Besides the inhibitory effect on macrophages, CD200/CD200R also play an important role in regulating the regulatory T cells, allergicreaction, autoimmune diseases, allograft, neurological diseases and other autoimmune-related diseases.The interaction between CD200, which is mainly present in neurons but also in astrocytes, and CD200R1, which is mainly present in microglia, is one of the mechanisms involved in keeping the microglial proinflammatory phenotype under control in physiological conditions. Alterations in the expression of CD200 and CD200R1 have been described in neurodegenerative diseases, but little is known about the mechanism of regulation of these proteins under physiological or pathological conditions.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
LY-3454738 LY-3454738 Eli Lilly And Company Details
P-006 23ME-00610; 23ME-610; P-006 Phase 1 Clinical 23andme Inc Solid tumours Details

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